Welcome to the Dynein homepage, hosted in the Faculty of Biological Sciences at the University of Leeds.
Recent Publications
The 2.8 Å crystal structure of the dynein motor domain.
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G. (2012)
Nature. 484(7394):345-350 Link
Insights into dynein motor domain function from a 3.3-Å crystal structure.
Schmidt H, Gleave ES, Carter AP. (2012)
Nat Struct Mol Biol. [Epub ahead of print] Link
Large-scale vortex lattice emerging from collectively moving microtubules.
Sumino Y, Nagai KH, Shitaka Y, Tanaka D, Yoshikawa K, Chaté H, Oiwa K. (2012)
Nature. 483(7390):448-452. Link
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. (2012)
Nature. 484(7392):125-129. Link
Two independent switches regulate cytoplasmic dynein's processivity and directionality.
Walter WJ, Koonce MP, Brenner B, Steffen W. (2012)
Proc Natl Acad Sci U S A. 109(14):5289-5293. Link
Multiple modes of cytoplasmic dynein regulation.
Vallee RB, McKenney RJ, Ori-McKenney KM. (2012)
Nat Cell Biol. 14(3):224-230. Link
Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes.
Amrute-Nayak M, Bullock SL. (2012)
Nat Cell Biol. 14(4):416-423. Link
Dynein achieves processive motion using both stochastic and coordinated stepping.
Qiu W, Derr ND, Goodman BS, Villa E, Wu D, Shih W, Reck-Peterson SL. (2012)
Nat Struct Mol Biol. 9(2):193-200. Link
Cytoplasmic Dynein Moves Through Uncoordinated Stepping of the AAA+ Ring Domains.
Dewitt MA, Chang AY, Combs PA, Yildiz A. (2011)
Science. 335(6065):221-225. Link
Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport.
Kunwar A, Tripathy SK, Xu J, Mattson MK, Anand P, Sigua R, Vershinin M, McKenney RJ, Yu CC, Mogilner A, Gross SP. (2011)
Proc Natl Acad Sci U S A. 108(47):18960-18965. Link
Three-dimensional structure of the radial spokes reveals heterogeneity and interactions with dyneins in Chlamydomonas flagella.
Barber CF, Heuser T, Carbajal-Gonzalez BI, Botchkarev VV Jr, Nicastro D. (2011)
Mol Biol Cell. 23(1):111-120. Link
Cryoelectron tomography of radial spokes in cilia and flagella.
Pigino G, Bui KH, Maheshwari A, Lupetti P, Diener D, Ishikawa T. (2011)
J Cell Biol. 195(4):673-687. Link
High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport.
Yi JY, Ori-McKenney KM, McKenney RJ, Vershinin M, Gross SP, Vallee RB. (2011)
J Cell Biol. 195(2):193-201. Link
The mechanism of dynein motility: Insight from crystal structures of the motor domain.
Cho C, Vale RD. (2011)
Biochim Biophys Acta. 1823(1):182-191. Link