Welcome to the Dynein homepage, hosted in the Faculty of Biological Sciences at the University of Leeds.

 

Meeting Announcements

Information on the exciting meetings taking place in 2013 is available.

The 3rd Dynein Workshop will be held in Japan on 31 October - 3 November 2013. Registration is due to open on 1 June 2013. Click here to download a PDF with further details.

 

Recent Publications

Functions and mechanics of dynein motor proteins.


Roberts AJ, Kon T, Knight PJ, Sutoh K, Burgess SA. (2013)

Nat. Rev. Mol. Cell Biol. [Epub ahead of print] Link

 


JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.


Fu MM, Holzbaur EL.(2013)

J Cell Biol. 202(3):495-508. Link

 

Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring.


Ananthanarayanan V, Schattat M, Vogel SK, Krull A, Pavin N, Toli?-Nørrelykke IM. (2013)

Cell. 153(7):1526-1536. Link

 

Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement.

Yamada M, Kumamoto K, Mikuni S, Arai Y, Kinjo M, Nagai T, Tsukasaki Y, Watanabe TM, Fukui M, Jin M, Toba S, Hirotsune S. (2013)

Nat Commun. 2013 Jun 19;4:2033. doi: 10.1038/ncomms3033. Link

 

The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility.


Yamamoto R, Song K, Yanagisawa HA, Fox L, Yagi T, Wirschell M, Hirono M, Kamiya R, Nicastro D, Sale WS. (2013)

J. Cell Biol. 201(2):263-278. Link

 

Crystal clear insights into how the dynein motor moves.

Carter AP. (2013)

J. Cell Sci. 126(Pt 3):705-713. Link

 


Molecular Adaptations Allow Dynein to Generate Large Collective Forces inside Cells.

Rai AK, Rai A, Ramaiya AJ, Jha R, Mallik R. (2013)

Cell. 152(1-2):172-182. Link

 

Calaxin drives sperm chemotaxis by Ca2+-mediated direct modulation of a dynein motor.

Mizuno K, Shiba K, Okai M, Takahashi Y, Shitaka Y, Oiwa K, Tanokura M, Inaba K. (2012)

Proc Natl Acad Sci U S A. 109(50):20497-20502.

 

Structural basis for microtubule binding and release by dynein.

Redwine WB, Hernández-López R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. (2012)

Science. 337(6101):1532-1536.

 

Lis1 Acts as a "Clutch" between the ATPase and Microtubule-Binding Domains of the Dynein Motor.

Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. (2012)

Cell. 150(5):975-986.

 

LIS1 Clamps Dynein to the Microtubule.

Trokter M, Surrey T. (2012)

Cell. 150(5):877-879.


A single protofilament is sufficient to support unidirectional walking of Dynein and Kinesin.

Shibata K, Miura M, Watanabe Y, Saito K, Nishimura A, Furuta K, Toyoshima YY. (2012)

PLoS One. 7(8):e42990.


Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axoneme.

Bui KH, Yagi T, Yamamoto R, Kamiya R, Ishikawa T. (2012)

J Cell Biol. 198(5):913-925.


ATP-Driven Remodeling of the Linker Domain in the Dynein Motor.

Roberts AJ, Malkova B, Walker ML, Sakakibara H, Numata N, Kon T, Ohkura R, Edwards TA, Knight PJ, Sutoh K, Oiwa K, Burgess SA. (2012)

Structure. 20(10):1670-1680.


Association of Lis1 with outer arm dynein is modulated in response to alterations in flagellar motility.

Rompolas P, Patel-King RS, King SM. (2012)

Mol Biol Cell. 23(18):3554-3565.


The CSC connects three major axonemal complexes involved in dynein regulation.

Heuser T, Dymek EE, Lin J, Smith EF, Nicastro D. (2012)

Mol Biol Cell. 23(16):3143-3155.


Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein.

Heuser T, Barber CF, Lin J, Krell J, Rebesco M, Porter ME, Nicastro D. (2012)

Proc Natl Acad Sci U S A. 109(30):E2067-2076.


Lis1 is an initiation factor for dynein-driven organelle transport.

Egan MJ, Tan K, Reck-Peterson SL. (2012)

J Cell Biol. 197(7):971-982.

 

The 2.8 Å crystal structure of the dynein motor domain.

Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G. (2012)

Nature. 484(7394):345-350 Link

 

Insights into dynein motor domain function from a 3.3-Å crystal structure.

Schmidt H, Gleave ES, Carter AP. (2012)

Nat Struct Mol Biol. 281(20):14006-14014. Link

 

Large-scale vortex lattice emerging from collectively moving microtubules.

Sumino Y, Nagai KH, Shitaka Y, Tanaka D, Yoshikawa K, Chaté H, Oiwa K. (2012)

Nature. 483(7390):448-452. Link

 

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.

Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. (2012)

Nature. 484(7392):125-129. Link

 

Two independent switches regulate cytoplasmic dynein's processivity and directionality.

Walter WJ, Koonce MP, Brenner B, Steffen W. (2012)

Proc Natl Acad Sci U S A. 109(14):5289-5293. Link

 

Multiple modes of cytoplasmic dynein regulation.

Vallee RB, McKenney RJ, Ori-McKenney KM. (2012)

Nat Cell Biol. 14(3):224-230. Link


Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes.

Amrute-Nayak M, Bullock SL. (2012)

Nat Cell Biol. 14(4):416-423. Link