Welcome to the Dynein homepage, hosted in the Faculty of Biological Sciences at the University of Leeds.

Recent Publications

Functions and mechanics of dynein motor proteins

Roberts AJ, Kon T, Knight PJ, Sutoh K, Burgess SA. (2013)
Nat. Rev. Mol. Cell Biol. [Epub ahead of print] Link

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

Fu MM, Holzbaur EL.(2013)
J Cell Biol. 202(3):495-508. Link

Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring

Ananthanarayanan V, Schattat M, Vogel SK, Krull A, Pavin N, Toli?-Nørrelykke IM. (2013)
Cell. 153(7):1526-1536. Link

Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement

Yamada M, Kumamoto K, Mikuni S, Arai Y, Kinjo M, Nagai T, Tsukasaki Y, Watanabe TM, Fukui M, Jin M, Toba S, Hirotsune S. (2013)
Nat Commun. 2013 Jun 19;4:2033. doi: 10.1038/ncomms3033. Link

The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility

Yamamoto R, Song K, Yanagisawa HA, Fox L, Yagi T, Wirschell M, Hirono M, Kamiya R, Nicastro D, Sale WS. (2013)
J. Cell Biol. 201(2):263-278. Link

Crystal clear insights into how the dynein motor moves

Carter AP. (2013)
J. Cell Sci. 126(Pt 3):705-713. Link

Molecular Adaptations Allow Dynein to Generate Large Collective Forces inside Cells

Rai AK, Rai A, Ramaiya AJ, Jha R, Mallik R. (2013)
Cell. 152(1-2):172-182. Link

Calaxin drives sperm chemotaxis by Ca2+-mediated direct modulation of a dynein motor

Mizuno K, Shiba K, Okai M, Takahashi Y, Shitaka Y, Oiwa K, Tanokura M, Inaba K. (2012)
Proc Natl Acad Sci U S A. 109(50):20497-20502.

Structural basis for microtubule binding and release by dynein

Redwine WB, Hernández-López R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. (2012)
Science. 337(6101):1532-1536.

Lis1 Acts as a "Clutch" between the ATPase and Microtubule-Binding Domains of the Dynein Motor

Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. (2012)
Cell. 150(5):975-986.

LIS1 Clamps Dynein to the Microtubule

Trokter M, Surrey T. (2012)
Cell. 150(5):877-879.

A single protofilament is sufficient to support unidirectional walking of Dynein and Kinesin

Shibata K, Miura M, Watanabe Y, Saito K, Nishimura A, Furuta K, Toyoshima YY. (2012
PLoS One. 7(8):e42990.

Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axoneme

Bui KH, Yagi T, Yamamoto R, Kamiya R, Ishikawa T. (2012)
J Cell Biol. 198(5):913-925.

ATP-Driven Remodeling of the Linker Domain in the Dynein Motor

Roberts AJ, Malkova B, Walker ML, Sakakibara H, Numata N, Kon T, Ohkura R, Edwards TA, Knight PJ, Sutoh K, Oiwa K, Burgess SA. (2012)
Structure. 20(10):1670-1680.

Association of Lis1 with outer arm dynein is modulated in response to alterations in flagellar motility

Rompolas P, Patel-King RS, King SM. (2012)
Mol Biol Cell. 23(18):3554-3565.

The CSC connects three major axonemal complexes involved in dynein regulation

Heuser T, Dymek EE, Lin J, Smith EF, Nicastro D. (2012)
Mol Biol Cell. 23(16):3143-3155.

Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein

Heuser T, Barber CF, Lin J, Krell J, Rebesco M, Porter ME, Nicastro D. (2012)
Proc Natl Acad Sci U S A. 109(30):E2067-2076.

Lis1 is an initiation factor for dynein-driven organelle transport

Egan MJ, Tan K, Reck-Peterson SL. (2012)
J Cell Biol. 197(7):971-982.

The 2.8 Å crystal structure of the dynein motor domain

Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G. (2012)
Nature. 484(7394):345-350 Link

Insights into dynein motor domain function from a 3.3-Å crystal structure

Schmidt H, Gleave ES, Carter AP. (2012)
Nat Struct Mol Biol. 281(20):14006-14014. Link

Large-scale vortex lattice emerging from collectively moving microtubules

Sumino Y, Nagai KH, Shitaka Y, Tanaka D, Yoshikawa K, Chaté H, Oiwa K. (2012)
Nature. 483(7390):448-452. Link

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. (2012)
Nature. 484(7392):125-129. Link

Two independent switches regulate cytoplasmic dynein's processivity and directionality

Walter WJ, Koonce MP, Brenner B, Steffen W. (2012)
Proc Natl Acad Sci U S A. 109(14):5289-5293. Link

Multiple modes of cytoplasmic dynein regulation

Vallee RB, McKenney RJ, Ori-McKenney KM. (2012)
Nat Cell Biol. 14(3):224-230. Link

Single-molecule assays reveal that RNA localization signals regulate dynein-dynactin copy number on individual transcript cargoes

Amrute-Nayak M, Bullock SL. (2012)
Nat Cell Biol. 14(4):416-423. Link